Recombinant Chicken RAF proto-oncogene serine/threonine-protein kinase (RAF1), partial

中文名稱：

雞RAF1重組蛋白
貨號：

CSB-YP019284CH
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

雞RAF1重組蛋白
貨號：

CSB-EP019284CH
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

雞RAF1重組蛋白
貨號：

CSB-EP019284CH-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

雞RAF1重組蛋白
貨號：

CSB-BP019284CH
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

雞RAF1重組蛋白
貨號：

CSB-MP019284CH
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

RAF1
Uniprot No.：

P05625
別名：

RAF1; MIL; RAF proto-oncogene serine/threonine-protein kinase; EC 2.7.11.1; C-MIL; C-RAF; MIL proto-oncogene serine/threonine-protein kinase; RAF-1
種屬：

Gallus gallus (Chicken)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2).
基因功能參考文獻：
1. RAF kinase activity is essential to establish the balance between cell proliferation and death in neuroepithelial otic precursors, and for otic neuron differentiation and axonal growth at the acoustic-vestibular ganglion PMID: 21203386
2. a complete map of the c-mil/raf-1 gene and a revision of the exon numbers PMID: 14968114
3. Inducible gene deletion of the c-mil/raf-1 gene in chicken DT40 B cells revealed that, in addition to B-Raf, Raf-1 acts as an accessory ERK activator following engagement of the B cell antigen receptor. PMID: 12411479
亞細胞定位：

Cytoplasm. Cell membrane.
蛋白家族：

Protein kinase superfamily, TKL Ser/Thr protein kinase family, RAF subfamily
組織特異性：

Isoform 1 was present in all tissues tested: skeletal muscle, intestine, brain, gizzard, heart, lung, kidney, bone marrow, spleen and bursa of Fabricius. Isoform 2 was only detected in brain, heart and skeletal muscle. In brain and heart isoform 1 is more
數據庫鏈接：

KEGG: gga:396245

STRING: 9031.ENSGALP00000007991

UniGene: Gga.42842